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Sodium restriction and insulin resistance: A review of 23 clinical trials

February 19, 2025

Sodium restriction and insulin resistance: A review of 23 clinical trials

Article

Many clinicians recommend low-salt diets for lowering blood pressure but there may be unintended consequences such as worsening insulin resistance.

Indeed, a lack of sodium has been shown to increase insulin levels, which may be a compensatory mechanism to help the kidneys retain sodium.

Additionally, low-salt diets elevate stress hormones, such as noradrenaline, aldosterone, renin and angiotensin-II, which contribute to vascular stiffening and vascular and systemic insulin resistance.

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